Publications
2026
Communication Medicine·2026
Polygenic risk-informed white matter integrity improves deep learning-based prediction of youth depressionMin JJ, Wang HH, Lee E, Kim B, Kin G, Choi SY, Choi K, Hong SH, Jang Y, Rah YU, Kim JY, Han S, Lee KH, Kimg J, Dijk M, Kim J, Chung G, Chung D, Lee SA, Joo YY & Cha J
Polygenic PredictionMedical AIMental HealthThe Lancet Diabetes & Endocrinology·2026
Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestriesHuerta-Chagoya A, Kim J, Mandla R et al.
Polygenic Prediction
2025
Journal of Child Psychology and Psychiatry·2025
Individual Differences in Effects of Stressful Life Events on Childhood ADHD: Genetic, Neural, and Familial ContributionsChoi SY, Yi J, Park J, Lee E, Kim BG, Kim G, Joo YY, Cha J
Mental HealthPolygenic PredictionMedical AINature Communications·2025
Polygenic architecture of brain structure and function, behaviors, and psychopathologies in childrenJoo YY*, Kim BG*, Kim G*, Lee E*, Seo J, Cha J
Medical AIPolygenic PredictionMental HealthImaging Genetics & NeurogeneticsMolecular Psychiatry·2025
Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathologyLee E*, van Dijk MT*, Kim BG, Kim G, Murphy E, Talati A, Joo YY, Weissman MM, Cha J
Imaging Genetics & NeurogeneticsMental HealthPolygenic Prediction
2024
Journal of Korean Medical Science·2024
Similar but Distinct Comorbidity Patterns Between Polycystic Ovary Syndrome and Endometriosis in Korean Women: A Nationwide Cohort StudyJeong HG*, Jeon M*, Ryu KJ, Kim J, Choe BY, Joo YY*, Park H*
Electronic Health RecordsElife·2024
Gene–environment pathways to cognitive intelligence and psychotic-like experiences in childrenPark J, Lee E, Cho G, Hwang H, Kim BG, Kim G, Joo YY*, Cha J*
Imaging Genetics & NeurogeneticsMental HealthPolygenic PredictionJournal of Psychiatric Research·2024
Multimodal integration of neuroimaging and genetic data for the diagnosis of mood disorders based on computer vision modelsLee S*, Cho Y*, Ji Y, Jeon M, Kim A, Ham BJ*, Joo YY*
Electronic Health RecordsMedical AIImaging Genetics & NeurogeneticsMental HealthPolygenic PredictionBMC Research Notes 17·2024
Genetic sex validation for sample tracking in next-generation sequencing clinical testingHu J, Korchina V, Zouk H, Harden MV, Murdock D, Macbeth A, Harrison SM, Lennon N, Kovar C, Balasubramanian A, Zhang L, G Chandanavelli, D Pasham, R Rowley, K Wiley, ME Smith, A Gordon, GP Jarvik, P Sleiman, MA Kelly, HT Bland, M Murugan, E Venner, E Boerwinkle, eMERGE III consortium, C Prows, L Mahanta, HL Rehm, RA Gibbs, DM Muzny
Electronic Health RecordsGenomics & Multi-omicsNature genetics·2024
Genetic drivers of heterogeneity in type 2 diabetes pathophysiologySuzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GE, Kanoni S, Rayner NW et al
Genomics & Multi-omicsHeliyon·2024
Early life stress modulates the genetic influence on brain structure and cognitive function in childrenWang HH*, Moon SY*, Kim H, Kim G, Ahn WY, Joo YY*, Cha J*
Imaging Genetics & NeurogeneticsPolygenic PredictionMental Health
2023
Journal of Investigative Dermatology·2023
Topical ozone accelerates diabetic wound healing by promoting re-epithelialization via activation of IGF1R-EGFR signalingLu JY, Wang XQ, Fu Z, Gao L, Mannam H, Xiang Y, Joo YY, Zeng J, Wang D, Paller AS
BMC Genomic Data·2023
Overestimated Polygenic Prediction due to Overlapping Subjects in Genetic DatasetsPark DK, Chen M, Kim S, Joo YY, Loving RK, Kim HS, Cha J, Yoo S, Kim JH
Polygenic PredictionPLoS One·2023
Multi-ancestry genome- and phenome-wide association studies of diverticular disease in electronic health records with natural language processing enriched phenotyping algorithmJoo YY, Pacheco JA, Thompson WK, Rasmussen-Torvik LJ, Rasmussen LV, Lin FTJ, Andrade M, Borthwick KM, Bottinger E, Cagan A, Carrell DS, Denny JC, Ellis SB, Gottesman O, Linneman JG, Pathak J, Peissig PL, Shang N, Tromp G, Veerappan A, Smith ME, Chisholm RL, Gawron AJ, Hayes MG, Kho AN
Electronic Health RecordsMedical AIGenomics & Multi-omicsJAMA Network Open·2023
National Trends in sadness and suicidality among Korean adolescents in 2005-2021: a nationwide representative study in 1.1 million individualsPark S, Yon H, Lee SW, Koyanagi A, Jacob L, Smith L, Cho W, Min C, Lee J, Lee H, Kwon R, Fond G, Boyer L, Rhee SY, Joo YY, Shin JI, Woo HG, Yon DK
Electronic Health RecordsMental HealthJournal of Child Psychology and Psychiatry·2023
Maternal age at birth and child attention‐deficit hyperactivity disorder: causal association or familial confounding?Baker BH, Joo YY, Park J, Cha J, Baccarelli AA, Posner J
Polygenic PredictionReproductive & Maternal HealthMental Health
2022
Frontiers in Endocrinology·2022
Misperception of body weight and associated socioeconomic and health-related factors among Korean female adults: A nationwide population-based studyJoo YY, Kim J, Lee K, Cho GJ, Yi KW
Electronic Health RecordsMedical AINature·2022
Genetic diversity fuels gene discovery for tobacco and alcohol useSaunders GR, Wang X, Chen F, Jang SK, Liu M, Wang C, Gao S, Jiang Y, Khunsriraksakul C, Otto JM, Addison C, et al
Genomics & Multi-omicsCancer medicine·2022
Statin use in patients with hormone receptor‐positive metastatic breast cancer treated with everolimus and exemestaneLee K, Noh E, Moon SJ, Joo YY, Kang EJ, Seo JH, Park IH
Electronic Health RecordsGenes·2022
Cognitive Capacity Genome-Wide Polygenic Scores Identify Individuals with Slower Cognitive Decline in AgingJoo YY, Cha J, Freese J, Hayes MG
Polygenic PredictionAgingMental HealthMedical AIGenomics & Multi-omicsNature genetics·2022
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translationMahajan A, Spracklen CN, Zhang W, Ng MC, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ, Horikoshi M et al
Genomics & Multi-omicsHuman Brain Mapping·2022
The sexual brain, genes, and cognition: A machine‐predicted brain sex score explains individual differences in cognitive intelligence and genetic influence in young childrenKim K, Joo YY, Ahn G, Wang HH, Moon SY, Kim H, Ahn WY, Cha J
Imaging Genetics & NeurogeneticsPolygenic PredictionJAMA network open·2022
Association of genome-wide polygenic scores for multiple psychiatric and common traits in preadolescent youths at risk of suicideJoo YY, Moon SY, Wang HH, Kim H, Lee EJ, Kim JH, Posner J, Ahn WY, Choi I, Kim JW, Cha J
Mental HealthPolygenic PredictionMedical AIGenomics & Multi-omics
2021 & earlier
Genetics in Medicine·2021
Neptune: an environment for the delivery of genomic medicineVenner E, Yi V, Murdock DR, Kalla SE, Wu TJ, Sabo A, Li S, Meng Q, Tian X, Murugan M, Cohen M, Kovar C, Wei WQ, Chung WK, Weng C, Wiesner GL, Jarvik GP, Muzny D, Gibbs RA, eMERGE Consortium
Electronic Health RecordsHuman Genetics and Genomics Advances·2021
Genetic discovery and risk characterization in type 2 diabetes across diverse populationsPolfus LM, Darst BF, Highland H, Sheng X, Ng MCY, Below JE, Petty L, Bien S, Sim X, Wang W, Fontanillas P, Patel Y, Preuss M, Schurmann C, Du Z, Lu Y, Rhie SK, Mercader JM, Tusie-Luna T, González-Villalpando C, Orozco L, Spracklen CN, Cade BE, Jensen RA, Sun M, Joo YY, An P, Yanek LR, Bielak LF, Tajuddin S, Nicolas A, Chen G, Raffield L, Guo X, Chen W-M, Nadkarni GN, Graff M, Tao R, Pankow JS, Daviglus M, Qi Q, Boerwinkle EA, Liu S, Phillips LS, Peters U, Carlson C, Wikens LR, Le Marchand L, North KE, Buyske S, Kooperberg C, Loos RJF, Stram DO, Haiman CA
Electronic Health RecordsGenomics & Multi-omics
2020
Human Genetics and Genomics Advances·2020
Lessons learned from the eMERGE Network: balancing genomics in discovery and practiceeMERGE Consortium
Electronic Health RecordsBMJ open·2020
Secular trends in postpartum weight retention from 2003 to 2012: a nationwide, population-based, retrospective, longitudinal study in South KoreaJoo YY, Park JH, Choi S, Cho GJ
Electronic Health RecordsJournal of Clinical Endocrinology & Metabolism·2020
A polygenic and phenotypic risk prediction for Polycystic Ovary Syndrome evaluated by Phenome-wide association studiesJoo YY, Actkins K, Pacheco JA, Basile AO, Carroll R, Crosslin DR, Day F, Denny JC, Velez Edwards DR, Hakonarson H, Harley JB, Hebbring SJ, Ho K, Jarvik GP, Jones M, Karaderi T, Mentch FD, Meun C, Namjou B, Pendergrass S, Ritchie MD, Stanaway IB, Urbanek M, Walunas TL, Smith M, Chisholm RL, Kho AN, Davis L, Hayes MG, International PCOS Consortium
Electronic Health RecordsPolygenic PredictionMedical AIGenomics & Multi-omics
2019
The American Journal of Human Genetics·2019
Harmonizing Clinical Sequencing and Interpretation for the eMERGE III NetworkeMERGE Consortium
Electronic Health Records
2018
Genetic Epidemiology·2018
The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotypeStanaway IB, Hall TO, Rosenthal EA, Palmer M, Naranbhai V, Knevel R, Namjou-Khales B, Carroll RJ, Kiryluk K, Gordon AS, Linder J, Howell KM, Mapes BM, Lin FTJ, Joo YY, Hayes MG, Gharavi AG, Pendergrass SA, Ritchie MD, de Andrade M, Croteau-Chonka DC, Raychaudhuri S, Weiss ST, Lebo M, Amr SS, Carrell D, Larson EB, Chute CG, Rasmussen-Torvik LJ, Roy-Puckelwartz MJ, Sleiman P, Hakonarson H, Li R, Karlson EW, Peterson JF, Kullo IJ, Chisholm R, Denny JC, Jarvik GP, e MN, Crosslin DR
Electronic Health RecordsGenomics & Multi-omics